1-Methyl-1H-imidazole-4-sulphonyl chloride
1-methyl-1H-imidazole-4-sulfonyl chloride
CAS: 137049-00-4
Molecular Formula: C4H5ClN2O2S
1-Methyl-1H-imidazole-4-sulphonyl chloride - Names and Identifiers
1-Methyl-1H-imidazole-4-sulphonyl chloride - Physico-chemical Properties
| Molecular Formula | C4H5ClN2O2S |
| Molar Mass | 180.61 |
| Density | 1.60±0.1 g/cm3(Predicted) |
| Melting Point | 88-91°C |
| Boling Point | 366.9±15.0 °C(Predicted) |
| Flash Point | 175.7°C |
| Solubility | DMSO (Slightly) |
| Vapor Presure | 2.99E-05mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 0.18±0.70(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Stability | Moisture Sensitive |
| Sensitive | Moisture Sensitive |
| Refractive Index | 1.621 |
1-Methyl-1H-imidazole-4-sulphonyl chloride - Risk and Safety
| Risk Codes | R34 - Causes burns R29 - Contact with water liberates toxic gas R14 - Reacts violently with water R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S8 - Keep container dry. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S30 - Never add water to this product. S22 - Do not breathe dust. |
| UN IDs | 3261 |
| HS Code | 29332900 |
| Hazard Note | Irritant |
| Hazard Class | 8 |
1-Methyl-1H-imidazole-4-sulphonyl chloride - Introduction
1-methyl -1H-imidazole-4-sulfonyl chloride, chemical formula C4H5ClN2O2S, it is an important organic compound, has the following properties, uses, preparation and safety information:
Nature:
1-Methyl-1H-imidazole-4-sulfonyl chloride is a colorless to pale yellow liquid with a pungent odor. It is a strong acidic compound that can react with alkali to form the corresponding salts.
Use:
1-Methyl-1H-imidazole-4-sulfonyl chloride is widely used in the field of organic synthesis. It can be used as an acid chloride reagent to participate in a variety of important chemical reactions, such as esterification, acylation, carbonylation, etc. It can also be used as a protecting reagent for aromatic amines for protecting amino groups.
Preparation Method:
The general synthesis method is prepared by the reaction of 1-methyl -1H-imidazole with sulfonyl chloride. First, 1-methyl -1H-imidazole is reacted with sulfur trioxide to form 1-methyl -1H-imidazole-4-sulfonic acid; then, 1-methyl -1H-imidazole-4-sulfonic acid is reacted with thionyl chloride to give 1-methyl -1H-imidazole-4-sulfonyl chloride.
Safety Information:
1-methyl -1H-imidazole-4-sulfonyl chloride in the operation to comply with the general laboratory safety practices. It is an irritant substance and may cause irritation in contact with the skin and eyes. In the process of operation need to wear protective glasses, gloves and laboratory coats and other protective equipment. Avoid breathing its vapor, should be used in a well-ventilated place, and keep the container sealed. In case of accidental contact, rinse immediately with plenty of water and seek medical help.
Nature:
1-Methyl-1H-imidazole-4-sulfonyl chloride is a colorless to pale yellow liquid with a pungent odor. It is a strong acidic compound that can react with alkali to form the corresponding salts.
Use:
1-Methyl-1H-imidazole-4-sulfonyl chloride is widely used in the field of organic synthesis. It can be used as an acid chloride reagent to participate in a variety of important chemical reactions, such as esterification, acylation, carbonylation, etc. It can also be used as a protecting reagent for aromatic amines for protecting amino groups.
Preparation Method:
The general synthesis method is prepared by the reaction of 1-methyl -1H-imidazole with sulfonyl chloride. First, 1-methyl -1H-imidazole is reacted with sulfur trioxide to form 1-methyl -1H-imidazole-4-sulfonic acid; then, 1-methyl -1H-imidazole-4-sulfonic acid is reacted with thionyl chloride to give 1-methyl -1H-imidazole-4-sulfonyl chloride.
Safety Information:
1-methyl -1H-imidazole-4-sulfonyl chloride in the operation to comply with the general laboratory safety practices. It is an irritant substance and may cause irritation in contact with the skin and eyes. In the process of operation need to wear protective glasses, gloves and laboratory coats and other protective equipment. Avoid breathing its vapor, should be used in a well-ventilated place, and keep the container sealed. In case of accidental contact, rinse immediately with plenty of water and seek medical help.
Last Update：2024-04-10 22:29:15
